Negative Feedback, Homeostasis, and Positive Feedback

Analysis and discussion questions develop student understanding of negative and positive feedback and homeostasis.

For example, students develop a model of negative feedback regulation of body temperature; this model includes a temperature control center in the brain that uses information about differences between a setpoint and actual body temperature to regulate sweating, shivering, and changes in blood flow to the skin.

The setpoint for negative feedback can be changed; for example, in response to an infection the temperature setpoint can be increased, resulting in a fever.

Negative feedback contributes to homeostasis.

Sometimes negative feedback does not function properly; for example, diabetes results from abnormalities in negative feedback regulation of blood glucose levels.

Finally, students analyze how positive feedback contributes to rapid change (e.g., rapid formation of a platelet plug).

The Student Handout is available in the first two attached files and as a Google doc designed for use in distance learning and online instruction. (For additional instructions, see https://serendipstudio.org/exchange/bioactivities/Googledocs, especially item 7.) The Teacher Notes, available in the last two attached files, provide instructional suggestions and background information and explain how this activity is aligned with the Next Generation Science Standards.