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I have played this game before, but in my economics class in high school, with other people (anonymously), and with consequence--EXTRA CREDIT POINTS. Unfortunately, while I chose to cooperate and accept the points my opponent offered, he ended up with 4 extra credit points and I only got 2. And my grade in the class needed the extra credit more. Playing the game in econ was to demonstrate the game theory.

But, since I knew how to play the game, I won against Serendip in 2 of the 3 games I played against it.  And the time I lost, it was only by 3 or 4 points. However, I like playing prisoner's dilemma with actual repercussions: for instance, imagining you are in jail and your accomplice can blame you, and you get jail time and they get off free, or you can blame them while they blame you and you both get jail time, or both of you can keep evidence hidden and get lessened jail sentences.