Pharmaceutical companies have been grappling with the placebo effect since the 1950s, when its surprising powers were discovered. As long as a patient is under the assumption that he or she is receiving a drug, a sugar pill or saline injection can alleviate illness and cure disease—sometimes, with close to the same level of efficacy as the actual drug. The science behind the placebo is shaky, and there are studies being conducted, but what seems to be of more concern to scientists is the placebo’s detriment to drug trials. Martin Enserink, in Science, discussed in his report on the placebo the recent failure of a new drug by Merck, MK-869, an antidepressant.