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This revised activity is aligned with the Next Generation Science Standards (see page 1 of the Teacher Preparation Notes). A major change has been the inclusion of a bioengineering design challenge where students work to find the optimum sucrose concentration and temperature to maximize rapid CO2 production, using no more sucrose than needed for maximum CO2 production. Structured questions guide the students through the basic engineering steps of applying the relevant scientific background, developing and systematically testing proposed design solutions, and then using their initial results to develop and test improved design solutions. Also, we have improved the scientific accuracy of the discussion of yeast metabolism.