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I was thinking about the same thing: I didn't realize just how small a change has to occur for such a serious issue to be created. This is really interesting to me, not only because, as Elizabeth said, it would be interesting to know how common these issues are, and if they can be corrected. It's also interesting because (and I know someone brought this up in class on Friday, but I don't remember who) having sickle cell anemia can make you immune to another disease (which I believe is malaria). Isn't it interesting that something so random (an accident, really) is turned into something that can, potentially, have a somewhat positive effect on someone's life? These are the kinds of questions I find so fascinating about biology.