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DNA

Introduction to Proteins and DNA

The Teacher Notes present a sequence of activities that will help students understand the basic structure and function of proteins and DNA.

To understand how genes influence our characteristics, students learn that different versions of a protein can result in different characteristics, and a gene in the DNA determines which version of a protein is synthesized by a person’s cells.

This information is conveyed through a PowerPoint with a sequence of discussion questions and videos, a Student Handout, and an optional hands-on learning activity. This sequence can be used in an introductory unit on biological molecules or to introduce a unit on molecular biology.

How Genes Can Cause Disease - Introduction to Transcription and Translation

Process of transcription and translation

To begin this hands-on, minds-on activity, students learn that different versions of a gene give the instructions for making different versions of a clotting protein, which result in normal blood clotting or hemophilia.

Then, students learn how genes provide the instructions for making a protein via the processes of transcription and translation. They develop an understanding of the roles of RNA polymerase, the base-pairing rules, mRNA, tRNA and ribosomes.

Finally, students use their learning about transcription and translation to understand how a change in a single nucleotide in the hemoglobin gene can result in sickle cell anemia.

Throughout, students use the information in brief explanations, figures and videos to answer analysis and discussion questions. In addition, students use simple paper models to simulate the processes of transcription and translation.

An alternative version omits the paper models (How Genes Can Cause Disease – Understanding Transcription and Translation).

Download Student Handout: PDF format or Word format

DNA

In this hands-on, minds-on activity, students extract DNA from Archaea or from their cheek cells.

In addition, students learn or review key concepts about the structure, function, and replication of DNA. For example, students learn that the genes in DNA give the instructions to make proteins, which influence our characteristics.

They also learn how the double helix structure of DNA and the base-pairing rules provide the basis for DNA replication.

This activity includes multiple analysis and discussion questions and hands-on or online modeling of DNA replication. (NGSS)

 Download Student Handout Archaea: PDF format or Word format

Download Teacher Preparation Notes Archaea: PDF format or Word format

Download Student Handout Cheek Cells: PDF format or Word format

Download Teacher Preparation Notes Cheek Cells: PDF format or Word format

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