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Paul Grobstein's picture

clinicial trials and "scientific rigor"

This paper raises some very interesting issues about the relationship between "scientific rigor" and "ethical behavior" that I would like to see further pursued.  Is it possible that the concern for "scientific rigor" can be relaxed in many cases where one is looking for large effects rather than small ones?  Is it possible that the "gold standard" of clinical research actually relates more to the needs to drug companies and liability issues than it does to effective health care? 

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