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The transition from the i-function to neuronal signaling seems somewhat unreasonable in that the transition is from a complicated higher function to the basics of how neurons work.　 it would seem more reasonable to transition from the basics to the more complex and demanding.　it would be something like understanding how horses walk before trying to explain how they gallop.　 the study of neurons would show that they all work in the same way.　the next step would be to look at the connections made up into pathways to see if some kind of organization of the neurons explains how higher functions are attained.　 all of this is highly physical.　higher functions may be more than physical?