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The terms "worlds" and "realities," in the plural, are misleading and unnecessary. It seems to make more sense to speak of one reality/ one world in which we all exist and about which we can know nothing with absolute certainty, on our own (without some sort of extrareality assistance). But, each person living in this world sees only a part of it and they see that part from a unique perspective. It is this that gives rise to the ideal of multiple realities. This jump to the idea of multiple realities is unnecessary and makes things more confusing then they need to be. We all find that our interactions with the world have varying degrees of success in accordance with how well our perception of the world match up to the thing itself. Perception here is more than just seeing things but also understanding cause and effect relationships between things. For example, if we treat a desk like it is a toilet and a toilet like a desk, we are going to have a bad day. This is an example of how we can misinterpret reality and act on our faulty interpretation. 

 The notion of mentally illness as being "out of touch with reality" fits this way of thinking fairly well as far as I can tell. The bigger question along this vain of thinking is "Why are some people's perceptions of reality worse than others?"

In this way of looking at the problem we can still move forward trying to figure out what "works best" and by that we can only mean figuring out which perceptions of reality are the best approximations of the real thing (about which we can have no certainty).

As a side note: I think there is something seriously wrong with thinking about a collection of jelly blobs as the necessary and sufficient substance for a human being. What I think of as "me" when I say that word I mean all of me, not just my brain or a part of that brain. To some extent I even consider my family and my friends to be a part of "me" so that if you hurt them, like hurting Christopher's toe you do hurt me even if I don't feel the pinch.