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I have to agree with Amelia here. Maybe it's because I only have experience with pathways in the form of molecular biological models that I can't buy the fMRI information 100% - the resolution simply isn't good enough. I think it's the best we've got as of yet and it is great for looking at correlations, but I think that instead of drawing conclusions that are tempting to draw from this information, we should focus efforts to improve methods of looking at the brain. (Easier said than done? Maybe?)

As frustrating as it is for science, I think it's beautiful that some people respond to drugs and others to therapy. As a scientist, naturally I want to know why, but it's almost comforting to know that there is individual difference - that we don't all respond the same way.