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Lots and lots of interesting issues brought up in our last discussion, and more so here. The upshot is that I had more to say than can fit reasonably here (see Kay Redfield Jamieson on Exuberance), so I put it elsewhere. See Exploring depression: drugs, psychotherapy, stories, conflicts, conscious/unconscious dissociation. The suggestion is that we take variability of therapeutic response seriously. Which is to say we stop arguing about drugs versus talk therapy (of various kinds) and start asking instead what are the observations actually telling us about how the brain works and what depression actually is. Along which lines, some expansion of the parallel between depression and motion sickness I briefly suggested during our conversation, and some more explicit development of what the nature of "conflict" is in the case of depression. For which, thanks Elna, thanks all.