Entering any art museum, you will walk down many white washed walls with brightly colored canvases mounted upon them. In the abstract section you will most likely pass a canvas that consists of only two or three large blocks of intense color painted upon it. Looking at these colored blocks, you may or may not experience a sense of sunniness, coolness, tenseness, or relaxation. This is a typical reaction to the works of Mark Rothko[1]. Rothko’s art, using alternately radiant and dark colors, is distinguished by the sustained concentration on pure pictorial properties such as color, surface, proportion, and scale, in order to inspire in his audience profound themes such as tragedy, ecstasy, and the sublime. His images are known to provoke raw human experiences, or what we have learned are primary experiences. Not only do his paintings evoke emotional states, they will not evoke the same emotion in everyone. How is Rothko able to achieve such a reactions and why do the reactions vary? I wish to look at this question from a biological and color-centric point of view, disregarding the I-function’s affect on creativity and variability in the brain.