Many people have heard of the ‘placebo effect.’ Placebo pills, sometimes known as sugar pills, are the gold standard control used to demonstrate the effectiveness of drug treatments for conditions like depression, ADHD, anxiety, and so on. These pills carry no useful medication, but can affect change solely through suggestion. However, a placebo must not always come in pill form. The placebo effect can be seen in injections and, perhaps more surprisingly, surgical procedures. This, coupled with the fact that the placebo effect can occur for a range of mental health and medical conditions, illustrates that even a simple sugar pill, and the expectation that it brings, can alter both our brain and physiological state.