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Next Generation Science Standards - Activity LIsting

Many of our activities for helping middle school and high school students learn life sciences are aligned with the Next Generation Science Standards (NGSS; http://www.nextgenscience.org/next-generation-science-standards). The following listing provides brief descriptions of our NGSS-related resources. The tables described in the first item below summarize the alignment of our activities with NGSS Disciplinary Core Ideas and Performance Expectations. These tables also summarize how each of these activities engages students in Scientific Practices and provides the opportunity to discuss Crosscutting Concepts. The Teacher Notes for each activity provide additional information concerning alignment with the Next Generation Science Standards.

Food, Energy and Body Weight

This analysis and discussion activity helps students to understand the relationships between food, energy, cellular respiration, and changes in body weight. Analysis of a representative scenario helps students to understand how challenging it is to prevent weight gain by exercising to offset what seems to be a relatively modest lunch.

In an optional research project, each student asks an additional question and prepares a report based on recommended reliable internet sources.

Gene Editing with CRISPR-Cas – A Potential Cure for Severe Sickle Cell Anemia

This analysis and discussion activity introduces Victoria Gray whose severe sickle cell anemia was effectively treated by gene editing with CRISPR-Cas.

To begin, students review the molecular biology of sickle cell anemia, transcription and translation.

Next, they learn how bacteria use CRISPR-Cas to defend against viral infections. Then, students examine some of the research findings that scientists used to identify the target for gene editing.

Finally, students analyze the CRISPR-Cas gene editing treatment for sickle cell anemia.

The Teacher Notes present an optional additional video and question to stimulate students to consider the ethical controversies related to potential uses of CRISPR-Cas.

Genetic Engineering Challenge – How can scientists develop a type of rice that could prevent vitamin A deficiency?

Parts of rice diagram

This analysis and discussion activity begins with an introduction to vitamin A deficiency and a review of transcription, translation, and the universal genetic code.

Several questions challenge students to design a basic plan that could produce a genetically engineered rice plant that makes rice grains that contain pro-vitamin A. Subsequent information and questions guide students as they learn how scientists use bacteria to insert desired genes, together with an appropriate promoter, in the DNA of plant cells.

In a final optional section, students evaluate the pro and con arguments in the controversy concerning Golden Rice.

Genetics

Photo of albino and non-albino children

This hands-on, minds-on activity helps students to understand basic principles of genetics, including (1) how genotype influences phenotype via the effects of genes on protein structure and function and (2) how genes are transmitted from parents to offspring through the processes of meiosis and fertilization.

Students use model chromosomes to demonstrate how meiosis and fertilization are summarized in Punnett squares.

In the coin flip activity, students learn about the probabilistic nature of inheritance and Punnett square predictions.

Genetics and Probability – Sex Ratios of Births

In this minds-on analysis and discussion activity, students analyze the inheritance of sex chromosomes. Students use a Punnett square to predict the sex ratio of births and compare their prediction to data for individual families and for the entire US.

As students analyze the reasons why many real families deviate from Punnett square predictions, they learn about the probabilistic nature of inheritance and the limitations of Punnett square predictions.

Genetics – Major Concepts, Common Misconceptions, and Learning Activities

Part I summarizes key concepts in genetics. Part II presents common misconceptions. Part III recommends an integrated sequence of learning activities on the biological basis of genetics, plus seven human genetics learning activities. These learning activities develop student understanding of key concepts and counteract common misconceptions. Each of these recommended learning activities supports the Next Generation Science Standards (NGSS).

How do muscles get the energy they need for athletic activity?

ATP in muscle cells

In this analysis and discussion activity, students learn how muscle cells produce ATP by aerobic cellular respiration, anaerobic fermentation, and hydrolysis of creatine phosphate. They analyze the varying contributions of these three processes to ATP production during athletic activities of varying intensity and duration.

Students learn how multiple body systems work together to supply the oxygen and glucose needed for aerobic cellular respiration.

Finally, students use what they have learned to analyze how athletic performance is improved by the body changes that result from regular aerobic exercise.

How do organisms use energy?

Enzymes convert substrates to productThis analysis and discussion activity introduces students to the basic principles of how organisms use energy.

The focus is on understanding the roles of ATP, cellular respiration, and hydrolysis of ATP.

In addition, students apply the principles of conservation of energy and conservation of matter to avoid common errors and correct common misconceptions. 

How do we sense the flavors of food?

Olfactory receptors and olfactory bulb sending messages to other parts of brainIn this minds-on, hands-on activity, students develop science practice skills by developing plans for a hands-on investigation, carrying out the investigation, analyzing the data, and interpreting the results.

Then, students answer analysis and discussion questions as they develop a basic understanding of how taste and olfactory receptor cells function and how sensory messages to the brain contribute to flavor perception and flavor-related behavior.

How does evolution result in similarities and differences?

Earthword, mealworm,and cricket

In this hands-on, minds-on activity, students analyze the similarities and differences between bat and squirrel skeletons and between bat and insect wings.

Students learn about the two ways that evolution produces similarities: (1) inheritance from shared evolutionary ancestors (homologous characteristics) and (2) independent evolution of similar characteristics to accomplish the same function (analogous characteristics).

In the laboratory investigation, students observe the external anatomy and locomotion of earthworms, mealworms, and crickets. Students use these observations and the concepts they have learned to figure out which two of these animals are more closely related evolutionarily. (NGSS)

Download Student Handout: PDF format or Word format

Download Teacher Preparation Notes: PDF format or Word format

How Eyes Evolved – Analyzing the Evidence

Human eye and octopus eye with lens and retina

This analysis and discussion activity focuses on two questions. How could something as complex as the human eye or the octopus eye have evolved by natural selection? How can scientists learn about the evolution of eyes, given that there is very little fossil evidence?

To answer these questions, students analyze evidence from comparative anatomy, mathematical modeling, and molecular biology. Students interpret this evidence to develop a likely sequence of intermediate steps in the evolution of complex eyes and to understand how each intermediate step contributed to increased survival and reproduction.

The Teacher Notes suggest additions to the Student Handout that can be used to introduce concepts such as the role of gene duplication in evolution and/or homology and analogy. 

How Genes Can Cause Disease - Introduction to Transcription and Translation

Process of transcription and translation

To begin this hands-on, minds-on activity, students learn that different versions of a gene give the instructions for making different versions of a clotting protein, which result in normal blood clotting or hemophilia.

Then, students learn how genes provide the instructions for making a protein via the processes of transcription and translation. They develop an understanding of the roles of RNA polymerase, the base-pairing rules, mRNA, tRNA and ribosomes.

Finally, students use their learning about transcription and translation to understand how a change in a single nucleotide in the hemoglobin gene can result in sickle cell anemia.

Throughout, students use the information in brief explanations, figures and videos to answer analysis and discussion questions. In addition, students use simple paper models to simulate the processes of transcription and translation.

An alternative version omits the paper models (How Genes Can Cause Disease – Understanding Transcription and Translation).

Download Student Handout: PDF format or Word format

How Genes Can Cause Disease – Understanding Transcription and Translation

Transcription with RNA nucleotides

In the first section of this analysis and discussion activity, students learn that different versions of a gene give the instructions for making different versions of a clotting protein, which result in normal blood clotting or hemophilia.

Next, students learn how genes provide the instructions for making a protein via the processes of transcription and translation. They develop an understanding of the roles of RNA polymerase, the base-pairing rules, mRNA, tRNA and ribosomes.

Finally, students use their learning about transcription and translation to understand how a change in a single nucleotide in the hemoglobin gene can result in sickle cell anemia.

Throughout this activity, students use the information in brief explanations, figures and videos to answer analysis and discussion questions.

This activity can be used to introduce students to transcription and translation or to reinforce and enhance student understanding. 

If you prefer a hands-on activity that uses simple paper models to simulate the molecular processes of transcription and translation, see “How Genes Can Cause Disease – Introduction to Transcription and Translation” (http://serendipstudio.org/sci_edu/waldron/#trans).

How have mutations and natural selection affected fur color in mice?

Four differently colored mice

In this analysis and discussion activity, students figure out how mutations and natural selection have resulted in matches between the fur colors of populations of rock pocket mice and their environments.

Next, students view a video that presents relevant research findings, and students answer the embedded multiple-choice questions.

Then, students answer multiple questions and analyze several scenarios to enhance their understanding of mutations and natural selection.

The Student Handout is available in the first two attached files and as a Google doc designed for use in online instruction and distance learning. The Teacher Notes, available in the last two attached files, provide instructional suggestions and background information and explain how this activity is aligned with the Next Generation Science Standards.

How Mistakes in Meiosis Can Result in Down Syndrome or Death of an Embryo

In this minds-on analysis and discussion activity, students learn how a mistake in meiosis can result in Down syndrome. Students also analyze karyotypes to learn how other mistakes in meiosis can result in the death of an embryo. Finally, students consider how a health problem can be genetic, but not inherited.

The Student Handout is available in the first two attached files and as a Google doc designed for use in online instruction and distance learning. The Teacher Notes, available in the last two attached files, provide instructional suggestions and background information and explain how this activity supports the Next Generation Science Standards (NGSS).

How to Reduce the Spread of COVID-19

In this activity, students analyze information about how the coronavirus is transmitted and how to reduce the risk of coronavirus infection. Several questions engage students in thinking about how their behavior influences the risk of COVID-19 for more vulnerable individuals.


Introduction to Cells

Organelles in animal and plant cells

This minds-on analysis and discussion activity begins with an anchor phenomenon – a video of a eukaryotic cell chasing and eating a bacterium. This leads to analyses of how cells carry out the activities of life and the similarities and differences between eukaryotic and prokaryotic cells.

Additional topics include the functions of the organelles in eukaryotic cells and the differences between animal and plant cells.

Introduction to Genetics – Similarities and Differences between Family Members

To begin this activity, students propose a hypothesis about how genes contribute to the similarities and differences in appearance of family members. Students repeatedly refine their hypothesis as they learn more.

Students learn that different versions of a gene give the instructions for making different versions of a protein which can result in different characteristics. Next, students review how genes are transmitted from parents to offspring through the processes of meiosis and fertilization. Then, students analyze several examples that illustrate how inheritance of genes can result in family resemblance and/or differences.

Concepts covered include Punnett squares, dominant and recessive alleles, incomplete dominance, and polygenic inheritance.

Introduction to Global Warming

To begin this minds-on analysis and discussion activity, students learn about the correlated increases in global temperatures and CO2 concentrations in the atmosphere.

Next, students evaluate an example that illustrates that correlation does not necessarily imply causation. Then, they analyze several types of evidence to test the hypothesis that increased CO2 in the atmosphere has been a major cause of the increase in global temperatures.

This activity concludes with a very brief discussion of how global warming has contributed to harmful effects (e.g., increased flooding) and possible actions to reduce these harmful effects.

Introduction to Osmosis

Comparison of animal cell and plant cellIn this hands-on, minds-on activity, students investigate the effects of hypotonic and hypertonic solutions on eggs that have had their shells removed. As students interpret their results, they develop a basic understanding of the process of osmosis. As they answer additional analysis and discussion questions, students learn about the effects of osmosis on animal and plant cells and apply their understanding of osmosis to the interpretation of several “real-world” phenomena.   

Download Student Handout: PDF format or Word format

Download Teacher Preparation Notes: PDF format or Word format

The Teacher Preparation Notes provide instructional suggestions and background information and explain how this activity is aligned with the Next Generation Science Standards.