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The overall direction of change in the universe is from less probable (more organized) states to more probable (less organized) states. Life does not "oppose" this but rather makes use of it. The "downhill" movement can be used to raise things "uphill" (just as water flowing downhill through a water wheel can be used to raise a weight). There is, however, always a net loss of organization in the process.
For life on earth, the dissipation of energy from the sun is the downhill movement. Photosynthesis creates "uphill" molecules which in turn can be used in cellular respiration to create additional "uphill" molecules from which, in turn, all of the "uphill" organization of life and culture derive.
All of biological and human organization represents a state of improbability very much less than that of the concentration of energy in the sun, and one which would quickly dissipate if the sun ceased shining (or there was some disturbance in the chain of water wheels which link the sun to biological and cultural organization).
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